The original building was designed for the Evangelisti family in the early 17th century by Giovanni Battista Mola, an architect of renown at the turn of the 17th century, who was celebrated for his clever mix of the classical and mannerist styles. As we are reminded by two plaques on the façade, the palace was later sold to the Venerable Confraternity of the Holy Trinity of the Pilgrims and Convalescents before being completely remodeled in the 18th century as the hunting lodge of the noble Guidi family.
In 2002, the palace was purchased by Count Goffredo Manfredi, a famous Italian entrepreneur and industrialist as well as one of the most prominent personalities of 20th-century Rome. Together with his wife, Countess Enrica – a descendent of the Russian Empress Catherine the Great on one side and the great English Romantic poet Percy Bysshe Shelley on the other – Count Manfredi was equally dedicated to his business ventures as he was to art and beauty, as evidenced by his elegant homes, where he loved to entertain high-profile members of the international jet set.
To honor the historic heritage of the Manfredi family, there is an epigraph with Cicero’s famous motto Virtute duce, comite fortuna (Virtue they leader, fortune thy comrade) on the façade of the small loggia at the top of the building.